A biomarker is a substance that could indicate a biologic state and is an objective measure to evaluate the current and future disease activity. 2016 Feb;245:62-70. doi: 10.1016/j.atherosclerosis.2015.11.019. in their systematic review and meta-analysis studied 13 studies and found that IL-1α and IL-1β (IL-1α (−889) C > T, IL-1α (+4845) G > T, IL-1β (+3954) C > T, could be a significant contribution to the risk of developing periodontitis [10]. Epub 2019 Jun 13. A meta-analysis by Mao et al., showed that IL-1β +3954 polymorphism increases the risk of periodontal disease [6]. Contact our London head office or media team here. Research has indicated that some people may be genetically susceptible to gum disease. The genetic basis of many aspects of the periodontal host response has been discussed in reference to genetic disorders predisposing to periodontal disease. in their meta-analysis found significant association between TGF-β SNP and periodontitis in Asian population. Consensus Report. Brief introduction to this section that descibes Open Access especially from an IntechOpen perspective, Want to get in touch? IL-1 β is produced by a wide range of periodontal tissues and immune cells and, as such, is considered to have multiple roles in innate and adaptive immune responses to plaque bacteria which feature in the pathogenesis of periodontitis [ 49. Our readership spans scientists, professors, researchers, librarians, and students, as well as business professionals. According to Li et al., there was no significant association of MMP1, 8, 9, 12, 2, or 13 polymorphism with periodontitis. The incidence of IL6 genotypes is reported to vary by ethnicity. Our team is growing all the time, so we’re always on the lookout for smart people who want to help us reshape the world of scientific publishing. Evaluating polymorphisms in COX-2 and MMP-2, MMP-3, MMP-8, and MMP-9 genes, two meta-analysis are available in literature [ … Periodontol 2000. The recent meta-analysis by Nibali et al. did not find any significant association of VDR Taq1 polymorphism with periodontitis in south Indian population [19]. Whereas PD leads to destruction of the tooth-supporting structures, CAD is a chronic inflammatory condition ultimately causing myocardial infarction via narrowing and occluding of blood vessels. There has been a rapid increase in interest in understanding the relationship between periodontal disease and cancer risk; twice as many original observational studies were published with measures of periodontal disease (i.e., not including studies using tooth number as surrogate of periodontal disease) in the past few years (n = 12; 2011–2016) as were published during the 20 years prior to 2011 (n = 6) (Web Tables 1 and 2, available at http://aje.oxfordjournals.org/). It exists in three isoforms TGF-β1, β2, and β3. in their meta-analysis based on 15 studies found an association between TNF-α SNP and periodontitis in Asian and Caucasian population [16]. found positive associations between IL-10 SNP and periodontitis in Swedish and Brazilian population [14]. postulated that a key determinant of whether individuals developed periodontitis or not was dependent on the way their bodies responded to the microbes [1]. Please enable it to take advantage of the complete set of features! Periodontitis and Cardiovascular Diseases. Thus, the genetic changes of the MMPs and TIMPs might play a role in the etiopathogenesis of periodontitis. has shown an association of two genetic loci (KCNK1 and DAB2IP) with high colonization of red complex bacteria. We are a community of more than 103,000 authors and editors from 3,291 institutions spanning 160 countries, including Nobel Prize winners and some of the world’s most-cited researchers. Classical twin studies led to the conclusion that both complex diseases have a similar degree of heritability and that a significant fraction of the genetic factors accounting for this heritability is shared. Whereas PD leads to destruction of the tooth-supporting structures, CAD is a chronic inflammatory condition ultimately causing myocardial infarction via narrowing and occluding of blood vessels. Fifteen papers meeting selection criteria were included in the qualitative review; the authors determined that meta-analysis could not be … A drug targeting an aging-related molecule reversed periodontal disease in elderly mice. Interleukin-6 is produced during inflammation by T cells. However, conflicting results have been obtained. The study by Divaris et al. A meta-analysis by Nikolopoulos et al., which based on 17 studies showed that there was no association of the TNF-α promoter −308G/A polymorphism with periodontitis while another meta-analysis by Song et al. in their systematic analysis listed top genes NIN, ABHD12B, WHAMM, AP3B2, CPEB1, HGD, ZNF675, EMK1, TNFRSF10B, HTR4, WDR59, JDP2, OTOF, ANGEL2, etc. Cui et al. As periodontal diseases (PDs) are among the most prevalent chronic infections in humans, there is a mounting scientific interest and public awareness of these possible interactions, mainly due to the like… Rhodin et al. HHS In a meta-analysis by Nikolopoulos et al. Available from: Diagnostic and Adjunctive Non-surgical Considerations, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India. Vitamin D and Vitamin D receptor are important mediators of bone metabolism. They seem to contribute to risk of periodontitis in Asian populations. While many organs can be affected, iron overload is especially likely to affect the liver, heart, and pancreas.Early symptoms of hemochromatosis can include fatigue, weakness, and joint pain. Remarkably, 3 of the PD loci (75%) show shared associations with CAD ( ANRIL/CDKN2B-AS1, PLG, CAMTA1/VAMP3), suggesting involvement of common pathogenic mechanisms. Subtle variations in the genetic code may result in altered expression of the encoded proteins, thereby making individuals with genotypes more susceptible to a given disease. Login to your personal dashboard for more detailed statistics on your publications. Priyanka et al. 2020 Feb 3;15(1):1. doi: 10.5334/gh.400. in their study found that Fok1 polymorphism was associated with periodontitis. Keywords: GWAS is a recent development in the field of research. 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